Alpha‐Synuclein co‐pathology drives tau accumulation in Alzheimer's disease patients and iPSCs‐derived models
We demonstrate that alpha-Synuclein co-pathology in AD is characterized by higher phosphorylated tau levels in patients and iPSC-derived neurons. Our results provide insights into the complex molecular processes through which alpha-Synuclein and tau synergistically drive dementia-related pathology.
Authors
- Qilin Tang
- Otto Windl
- Jeannine Widmann
- Thomas Köglsperger
- T. Arzberger
- Sigrun Roeber
- Jochen Herms (ORCID: https://orcid.org/0000-0002-6201-1042)
- Viktoria Ruf
- Federico Fierli (ORCID: https://orcid.org/0000-0002-8259-2067)
- Christian Haass
- Teodoro De Vecchi
- Felix Strübing
- Xiaoxuan Song
- Juliane Winkelmann
Institutions
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106193
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00