Socioeconomic deprivation and medical comorbidity burden associations with clinicopathologic characteristics in an ethnoracially diverse Alzheimer's disease autopsy series
Socioeconomic deprivation and most medical comorbidities were not associated with AD symptomatic onset. Despite having higher education levels and lower cerebrovascular burden, YOAD decedents experienced faster cognitive decline but a longer disease course, with more frequent atypical clinical presentations and depression compared to LOAD. Further discussion will address the topographic distribution of tangle and plaque pathology.
Authors
- Sara Dunlop
- Lauren E. Haydu (ORCID: https://orcid.org/0000-0002-6360-0199)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- John A. Lucas (ORCID: https://orcid.org/0000-0001-5805-8799)
- Lindsey A. Kuchenbecker (ORCID: https://orcid.org/0000-0002-2987-1040)
- Bailey Rawlinson
- Zhongwei Peng (ORCID: https://orcid.org/0000-0001-9342-4168)
- Sheina Emrani
- Erica Engelberg‐Cook
- Melissa E. Murray
- Idaly Velez‐Uribe
- Josalen Ventura
- Gregory S Day
- Christian Lachner
- Neill R. Graff‐Radford
Institutions
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107360
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00