Optimizing Alzheimer’s Disease Clinical Trials with Predictive Models of Cognitive Decline
Our results demonstrate that predictive models have the potential to optimize AD trial design by selecting participants expected to decline if treated with placebo and refining the analyses of treatment effects with prognostic adjustments.
Authors
- Tianchen Qian (ORCID: https://orcid.org/0000-0003-4282-7826)
- Bhargav Teja Nallapu
- Ali Ezzati
- Richard B. Lipton
Institutions
- Albert Einstein College of Medicine (US)
- University of California, Irvine (US)
- Delft University of Technology (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_098567
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00