Amygdala parcellation reveals unique subregions of atrophy in FTLD‐tauopathies
Results highlight the leftward asymmetry of disease in PPA and demonstrate increased atrophy of the amygdala in PPA/3R. Further, distinct portions of the amygdala were implicated in 3R versus 4R FTLD- tauopathy. Findings support prior research showing divergent neuropsychiatric phenotypes in FTLD-tauopathies, which may result from disruptions in amygdalar circuits governing emotional and behavioral processes. Future functional connectivity studies could offer greater insight into the pathways of limbic disruption in tauopathies.
Authors
- Jane Stocks (ORCID: https://orcid.org/0000-0002-1778-330X)
- T. Parrish
- Daniel Gutstein
- Tamar Gefen (ORCID: https://orcid.org/0000-0002-2380-3100)
- Marek M. Mesulam
- Rachel Keszycki (ORCID: https://orcid.org/0000-0001-7686-2959)
- Elena Barbieri (ORCID: https://orcid.org/0000-0002-3480-7983)
- Sandra Weintraub
- Changiz Geula
- Rudolph J Castellani
Institutions
- Northwestern University (US)
- Brown University (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100335
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00