Role of Locus Coeruleus Integrity in Slow‐Wave Activity in Alzheimer's Disease
These findings suggest that LC integrity contributes to SWA alterations in AD, highlighting its potential role in the disruption of sleep-related neurophysiological processes. This study emphasizes the importance of LC degeneration in the sleep pathology of AD and supports further exploration of LC-targeted interventions to address sleep and cognitive deficits.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Neus Falgàs (ORCID: https://orcid.org/0000-0002-3404-2765)
- Agnès Pérez‐Millan (ORCID: https://orcid.org/0000-0002-3006-9792)
- Aurora Arqueros
- Albert Lladó (ORCID: https://orcid.org/0000-0002-5066-4150)
- Gerard Piñol‐Ripoll (ORCID: https://orcid.org/0000-0002-4495-2113)
- Beatriz Bosch‐Capdevila
- Marta García Peña (ORCID: https://orcid.org/0000-0003-2622-5489)
- Andrea Val‐Guardiola
- Oriol Grau‐Rivera
- Núria Tort‐Colet
- Emma Muñoz‐Moreno
- Gerard Mayà
- Manuel Morales‐Ruiz
- Carles Gaig
- Álex Iranzo
- Raquel Sánchez‐Valle
Institutions
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Pasqual Maragall Foundation (ES)
- Hospital Clínic de Barcelona (ES)
- Barcelonaβeta Brain Research Center (ES)
- Global Brain Health Institute (US)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_096973
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00