Structure‐function decoupling in genetic frontotemporal dementia
Our findings demonstrate progressive de-coupling between structural connectivity and functional segregation over the course of genetic frontotemporal dementia. These results have implications for designing pre-symptomatic disease-modifying 'preventative' trials, supported by imaging-based surrogate markers of neural system dynamics.
Authors
- Maura Malpetti (ORCID: https://orcid.org/0000-0001-8923-9656)
- James B. Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Arabella Bouzigues (ORCID: https://orcid.org/0000-0002-0267-8590)
- Lucy L. Russell
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Elizabeth Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Christopher Butler (ORCID: https://orcid.org/0000-0002-0102-3453)
- Kamen A. Tsvetanov (ORCID: https://orcid.org/0000-0002-3178-6363)
- Caroline Graff
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Carmela M. Tartaglia
- Fabrizio Tagliavini
- Mario Masellis
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- Enrico Premi
- Jonathan D. Rohrer
- Rik Vandenberghe
- Daniela Galimberti
- John van Swieten
- Lize Jiskoot
- P Simon Jones
- Robert Laforce
- Raquel Sanchez‐Valle
- Fermin Moreno
- Sandro Sorbi
- Timothy Rittman
- Isabel Santana
- GENFI the Genetic FTD Initiative
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Lisbon (PT)
- University of Milan (IT)
- MRC Cognition and Brain Sciences Unit (GB)
- University of Cambridge (GB)
- Toronto Western Hospital (CA)
- German Center for Neurodegenerative Diseases (DE)
- Erasmus MC (NL)
- Hospitais da Universidade de Coimbra (PT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- University of Oxford (GB)
- Biogipuzkoa Health Research Institute (ES)
- Munich Cluster for Systems Neurology (DE)
- Don Carlo Gnocchi Foundation (IT)
- UK Dementia Research Institute (GB)
- Klinikum Arnsberg (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University Hospital Ulm (DE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Université Laval (CA)
- Sunnybrook Research Institute
- University of Florence (IT)
- University College London (GB)
- McGill University (CA)
- University of Coimbra (PT)
- University of Brescia (IT)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100438
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00