ADAPT: Atlas‐Driven Access to Postmortem Tissue
onnecting the digital BSP atlas to an ecosystem of diverse neuroscience atlases provides a versatile, scalable, user-oriented, and explicit solution to characterizing and locating brain biorepository resources, optimizing their use for interdisciplinary ADRD research. Incorporating neuroinformatics conventions simplifies incorporating additional atlases and enables compatibility with freely-available tools for advanced analysis and visualization. The web-enabled interface facilitates the rapid identification of biorepository samples likely to contain tissue with specific neurosciences attribute along with an estimated volume, lowering the barrier for collaboration between scientists in many fields of AD research. ADAPT can also provide explicit criteria for the optimality of samples for guiding and assessing the precision & accuracy of neuropathological sampling.
Authors
- Caitlin S. Latimer (ORCID: https://orcid.org/0000-0003-3727-4278)
- Thomas J. Grabowski (ORCID: https://orcid.org/0000-0002-7425-6610)
- Jason Webster
- Yiqin Alicia Shen (ORCID: https://orcid.org/0000-0002-7138-9290)
- Ali Shojaie (ORCID: https://orcid.org/0009-0000-7463-2914)
- Tung Thanh Le (ORCID: https://orcid.org/0000-0003-1564-4362)
- Christine MacDonald
- C. Dirk Keene
Institutions
- University of Washington (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107804
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00