post translational modifications in the brain are critical contributors to Alzheimer's disease neuropathology and cognitive decline
This proteome-wide examination of PTMs in the AD brain highlight known and novel PTMs in MAPT and APP, while also identifying novel protein PTMs related to amyloid, tau, and cognitive impairment. These results indicate vast changes to proteins during AD and highlight numerous novel targets for intervention.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Vladislav Petyuk (ORCID: https://orcid.org/0000-0003-4076-151X)
- Lisa Laverne Barnes
- Shahram Oveisgharan
- Philip L. De Jager
- Julie A Schneider
- David A. A. Bennett
- Julia B. Libby
Institutions
- Broad Institute (US)
- Rush University Medical Center (US)
- Pacific Northwest National Laboratory (US)
- Vanderbilt University (US)
- Columbia University Irving Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105864
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00