Impact of Neuropsychiatric Symptoms on Measures of Daily Functioning in Older Adults

In cognitively unimpaired older adults, greater overall NPS and greater affective symptoms, including depression, anxiety, anhedonia, and apathy, were associated with worse participant and study-partner-reported daily functioning performance. This relationship underscores the importance of recognizing and treating NPS for improving daily functioning and quality of life, even prior to the onset of overt cognitive impairment, and considering source of report and methods of IADL measurement when utilizing the latter as clinical trial outcome measures.