2,5‐ <i>Bis</i> (4‐phenethylpiperazin‐1‐yl)‐1,4‐benzoquinone: Harnessing AChE Selectivity for Alzheimer's Disease Therapy.

A synergistic effect of two structural components on the inhibitory activity against AChE has been anticipated. The synthetic analogue possessed selective AChE activity (IC₅₀ Value: 8.055 µmoles), an appreciable value of selectivity index (1.067) and significant antioxidant potential (Table 1). The ex vivo AChE inhibition assays complied with the behavioural studies data along with the docking results showing important interactions with AChE protein (Figure 1) CONCLUSION: The results showed memory restorative effect of the synthesized compound on scopolamine-induced memory impairment most likely being related to mediation of synaptic transmission in cholinergic system and their effective antioxidant activity. Hence, the results were appreciable and provided a promising lead which can further be explored for the development of selective AChE inhibitors.