Distinct Proteomic Alterations and Solubility Profiles in Primary Tauopathies
This study provides the first comparative analysis of protein solubility across tauopathies, revealing disease-specific proteomic signatures and divergent mechanisms. Our findings reveal key proteins and pathways linked to tau pathology, offering insights into tauopathy pathogenesis and discriminatory biomarkers.
Authors
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Evgeny Kanshin (ORCID: https://orcid.org/0000-0001-7142-4554)
- Stephanie Trgovcevic
- Eleanor Drummond
- Beatrix Ueberheide
- Tomas Kavanagh
- Laura Nementzik
Institutions
- The University of Sydney (AU)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107594
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00