Mitochondrial and Autophagy‐Related Proteins are Downregulated in the Brains of the rTg4510 Mouse Model of Tauopathy and Associated with Pain‐like Behavior in a Sex‐Dependent Manner

The findings in the rTg4510 model are considered relevant to dementias, as tau pathology and mitochondrial dysfunction are key features of the diseases. Currently, the rTg4510 model showed significant mitochondrial and autophagy-related protein downregulation, indicative of aberrant functioning in these pathways. These differences were related to pain-like behavior in the 2xTau Tg4510 group. Our findings provide insight into the relationship between pain and mitochondrial and autophagy dysregulation in tauopathies, especially in the earlier stages.