Sex dimorphism in AD mouse model: influence of APP‐mediated intracellular signaling on sleep, cognitive function, and the blood‐brain barrier
The close relationship between cognitive performance and BBB leakage, especially in female mice, indicates sex-dependent neurovascular unit impairment. Our results also demonstrated the significant contribution of APP-mediated signaling in restoring sleep and memory loss in an AD mouse model.
Authors
- A. Parent
- Mohammad Badran (ORCID: https://orcid.org/0000-0001-7073-741X)
- Anjana Sadanand
- Rong Wang (ORCID: https://orcid.org/0000-0003-4215-2574)
- Neil M. Coleman
- Clémentine Puech
- David Gozal
Institutions
- University of South Florida (US)
- University of Missouri (US)
- Marshall University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106042
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00