Targeting the MIR4435-2HG/miR-29c-3p/FSP1 axis overcomes lenvatinib resistance by inducing ferroptosis in hepatocellular carcinoma
Our findings identify a previously uncharacterized MIR4435-2HG/miR-29c-3p/FSP1 axis that promotes lenvatinib resistance by inhibiting ferroptosis, highlighting that targeting this axis may provide a mechanistic basis and preclinical rationale for overcoming lenvatinib resistance in HCC.
Authors
- Congyue Zhang (ORCID: https://orcid.org/0000-0002-7498-6576)
- Shaoya Li (ORCID: https://orcid.org/0000-0001-6917-4867)
- Xiaoqing Wu
- Jiawei Cui (ORCID: https://orcid.org/0000-0002-3547-9563)
- Zhandong Lin
- YueMin Nan
- Mengjiao Sun
- Yaoyao Mao
- Yue Shi
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei Seismological Bureau (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1186/s12935-025-04147-5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00