TL1A-activated T cells remodel the rectal mucosa in patients with Crohn’s disease with perianal fistulising disease
Our findings revealed unique cellular alterations in the rectum of patients with CD+PFD, highlighting the previously unrecognised involvement of TL1A in mediating this signature and supporting the need for exploring the role of TL1A inhibition as a therapeutic approach for PFD.
Authors
- R. F. Leal
- Iris Teubel (ORCID: https://orcid.org/0009-0006-6008-907X)
- Marisol Veny (ORCID: https://orcid.org/0000-0002-5702-4789)
- Martin Hemberg (ORCID: https://orcid.org/0000-0001-8895-5239)
- Cristina Prieto (ORCID: https://orcid.org/0000-0002-0812-8100)
- Julián Panés (ORCID: https://orcid.org/0000-0002-4971-6902)
- Berta Caballol (ORCID: https://orcid.org/0000-0002-7921-6730)
- Jae Won Cho (ORCID: https://orcid.org/0000-0003-2930-4836)
- Jordi Rimola (ORCID: https://orcid.org/0000-0002-1814-4198)
- Lori Robbins
- Victòria Gudiño (ORCID: https://orcid.org/0000-0003-1663-975X)
- Ingrid Ordàs
- Ángel Giner
- Míriam Esteller (ORCID: https://orcid.org/0000-0001-5770-9086)
- E Melón-Ardanaz
- M.-A. Esteve
- Ángela Sanzo-Machuca (ORCID: https://orcid.org/0000-0003-0457-8830)
- Azucena Salas
- Carme Loras
- Albert Martín-Cardona
- Isabella Dotti
- Maria Carme Masamunt
- Agnès Fernández-Clotet
- Elena Ferrer
- Elena Ricart
- Ana Corraliza
- Livia Moreira Genaro
Institutions
- Brigham and Women's Hospital (US)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Departament de Salut (ES)
- Hospital Clínic de Barcelona (ES)
- Mútua Terrassa (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Gut
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1136/gutjnl-2025-336246
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Ministerio de Ciencia e Innovación
- Agencia Estatal de Investigación