Protective Effects of Safranal Against Spike Protein-Induced Mitochondrial Dysfunction and Inflammation in Peripheral and Central Immune Cells
These findings identify safranal as a promising neuroprotective candidate for preventing or mitigating SARS-CoV-2-associated neurological damage and other disorders involving microglial activation and mitochondrial impairment.
Authors
- Miriam Buttacavoli (ORCID: https://orcid.org/0000-0003-4332-8228)
- Flores Naselli (ORCID: https://orcid.org/0009-0000-8075-0642)
- Picone Pasquale
- Martina Letizia Contente (ORCID: https://orcid.org/0000-0002-3885-1375)
- Gigliola Borgonovo (ORCID: https://orcid.org/0000-0003-3632-8799)
- Sabrina Dallavalle (ORCID: https://orcid.org/0000-0002-8813-8922)
- Antonella Girgenti
- Domenico Nuzzo
- Laura Palumbo
- Andrea Pinto
Institutions
- University of Milan (IT)
- Institute for Biomedical Research and Innovation (IT)
- National Research Council (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107629
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00