The association between tau‐related fluid biomarkers and synapse‐associated biomarkers in Alzheimer's disease

This study confirms that phosphorylated tau pathology is a critical pathway for synaptic damage. Plasma p-tau217 is closely associated with peripheral and brain synaptic changes, showing potential as a plasma biomarker for early screening and prediction of AD synaptic injury pathology.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_101974
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

The association between tau‐related fluid biomarkers and synapse‐associated biomarkers in Alzheimer's disease

Mengjie Wang
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

The association between tau‐related fluid biomarkers and synapse‐associated biomarkers in Alzheimer's disease

Mengjie Wang
article en

Abstract

This study confirms that phosphorylated tau pathology is a critical pathway for synaptic damage. Plasma p-tau217 is closely associated with peripheral and brain synaptic changes, showing potential as a plasma biomarker for early screening and prediction of AD synaptic injury pathology.

Alzheimer s & DementiaVol. 21(S2)
Fudan University (CN), Huashan Hospital (CN)
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
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The association between tau‐related fluid biomarkers and synapse‐associated biomarkers in Alzheimer's disease — Mengjie Wang · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS