Sleep Disruption in Early‐Onset Alzheimer's Disease
While subjective sleep measures were similar between EOAD and LOAD, actigraphy revealed more significant sleep disruption in EOAD. Notably, LC volume was uniquely reduced in EOAD, whereas other subcortical nuclei showed larger volumes than LOAD. These findings highlight the need to explore the role of subcortical degeneration in sleep disturbances in early-onset AD.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Agnès Pérez‐Millan (ORCID: https://orcid.org/0000-0002-3006-9792)
- Bea Bosch
- Adrià Tort‐Merino (ORCID: https://orcid.org/0000-0002-5646-0482)
- Guadalupe Fernández‐Villullas (ORCID: https://orcid.org/0000-0002-0569-1344)
- Andrea Val‐Guardiola
- Neus Falgàs Martínez
- Mircea Balasa
- Emma Muñoz‐Moreno
- Gerard Mayà
- Albert Lladó
- Marta Peña
- Álex Iranzo
- Raquel Sánchez‐Valle
- Carles Gaig
Institutions
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Hospital Clínic de Barcelona (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_099055
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00