Blood‐based genes and co‐expression network levels are associated with AD/MCI diagnosis, cognitive, and neuroimaging phenotypes and preserved in the brain
We identified blood transcripts and modules associated with AD/MCI, cognition, or neuroimaging, with three preserved in brain networks. These three modules represent centrally linked peripheral molecular signatures that can reveal perturbed brain pathways and cell level transcriptional changes in AD/MCI. We aim to further investigate the prioritized transcripts in additional datasets to establish them as potential novel biomarkers and therapeutic targets.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- R. C. Petersen
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- Denise Alexandra Chavez Reyes
- Mariet Allen (ORCID: https://orcid.org/0000-0002-2685-427X)
- Zachary Quicksall (ORCID: https://orcid.org/0000-0002-8791-0925)
- Andrew Joel Saykin
- Minerva M. Carrasquillo
- Kwangsik Nho
- Xuan Chen
- Nilüfer Ertekin‐Taner
- Thuy T. Nguyen
- Xue Wang
- Kejal Kantarci
Institutions
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100329
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00