Functional connectivity alterations of the default mode network in preclinical Alzheimer's disease
These findings suggest that increased FC within the DMN and decreased FC between the DMN are characteristic features of preclinical AD. While further studies are needed, the characteristic features of DMN FC in preclinical AD may result from compensatory network activation in response to early Aβ deposition.
Authors
- Evgeny J. Chumin (ORCID: https://orcid.org/0000-0001-6696-6105)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Yun‐Sang Lee
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-6613-4680)
- Woo‐Jin Cha
- Andrew Joel Saykin
- Kwangsik Nho
- Dahyun Yi
- Koung Mi Kang
- Olaf Sporns
- Chul‐Ho Sohn
- Dong Young Lee
- Joon Hyung Jung
- Shannon L Risacher
- Yu Kyeong Kim
Institutions
- Seoul National University (KR)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Indiana University Bloomington (US)
- Chungbuk National University Hospital (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100689
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00