Tau is associated with atrophy in MCI independently of beta‐amyloid and APOE e4 genotype

We determined that the distributed tau scores showed extended areas of statistical significance with cortical thickness. Although less spatially extended, the relative and absolute GM densities also showed areas of tau-related reductions. Our results suggest that in MCI, tau is associated with consistent atrophy patterns derived from different imaging biomarkers independently of beta-amyloid burden, reflecting a significant role of tau in neurodegeneration. References 1. Carbonell et al., J. Alzheimer Dis.,73: 543-557, 2020. 2. Carbonell et al., Alzheimer and Dementia, 2025, in press.