Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases
A single somatic variant in a few stem cells can remodel hematopoiesis, generating variable immune mosaics and heterogeneous immune disease.
Authors
- Rensing-Ehl Anne
- Richard Moriggl (ORCID: https://orcid.org/0000-0003-0918-9463)
- Roland Elling (ORCID: https://orcid.org/0000-0002-2209-4154)
- Carsten Speckmann (ORCID: https://orcid.org/0000-0001-7638-1151)
- Martin Broly (ORCID: https://orcid.org/0009-0005-4685-7063)
- Bertram Bengsch
- V. Schipperges
- Carla N. Castro (ORCID: https://orcid.org/0000-0002-2689-9072)
- Nina Cabezas‐Wallscheid (ORCID: https://orcid.org/0000-0003-0870-0530)
- Myriam Ricarda Lorenz (ORCID: https://orcid.org/0000-0002-3537-4550)
- Lea Seidel
- Björn Schulte
- Klaus Schwarz (ORCID: https://orcid.org/0000-0003-3178-5990)
- Jonathan Gehrig
- Jasmin Gï¿ ⁄ mann
- Tobias Suske
- Mathias Hauri
- Jean-Baptiste Gaillard
- Melanie Boerries
- Juncal Fernandez-Orth
- Arnaud Bourdin
- Peter Aichele
- Kristoffer Weißert
- Stephan Ehl
- Miriam Erlacher
- Lara Heller
- Maximilian Heeg
- Timothy Ronan Leahy
- Christoph König
- Geoffroy Andrieux
- Sarah Grün
- David Genevieve
- Julian Wolter-Mess
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Veterinary Medicine Vienna (AT)
- Inserm (FR)
- University of Freiburg (DE)
- University of Salzburg (AT)
- Universität Ulm (DE)
- Université de Montpellier (FR)
- University Medical Center Freiburg (DE)
- German Red Cross (DE)
- Children's Health Ireland at Crumlin (IE)
- Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Centre de Référence des Maladies Autoinflammatoires et des Amyloses (FR)
- CeGaT (Germany) (DE)
- University Children's Hospital Zurich (CH)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jaci.2025.12.993
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00