Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases

A single somatic variant in a few stem cells can remodel hematopoiesis, generating variable immune mosaics and heterogeneous immune disease.

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Publication Details

Journal
Journal of Allergy and Clinical Immunology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.jaci.2025.12.993
Primary Topic
Immunodeficiency and Autoimmune Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases

Rensing-Ehl Anne, Richard Moriggl, Roland Elling, Carsten Speckmann et al.
Journal of Allergy and Clinical Immunology
Immunodeficiency and Autoimmune Disorders
article

Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases

Rensing-Ehl Anne, Richard Moriggl, Roland Elling, Carsten Speckmann, Martin Broly, Bertram Bengsch, V. Schipperges, Carla N. Castro, Nina Cabezas‐Wallscheid, Myriam Ricarda Lorenz, Lea Seidel, Björn Schulte, Klaus Schwarz, Jonathan Gehrig, Jasmin Gï¿ ⁄ mann, Tobias Suske, Mathias Hauri, Jean-Baptiste Gaillard, Melanie Boerries, Juncal Fernandez-Orth, Arnaud Bourdin, Peter Aichele, Kristoffer Weißert, Stephan Ehl, Miriam Erlacher, Lara Heller, Maximilian Heeg, Timothy Ronan Leahy, Christoph König, Geoffroy Andrieux, Sarah Grün, David Genevieve, Julian Wolter-Mess
article en

Abstract

A single somatic variant in a few stem cells can remodel hematopoiesis, generating variable immune mosaics and heterogeneous immune disease.

Journal of Allergy and Clinical Immunology
Centre National de la Recherche Scientifique (FR), University of Veterinary Medicine Vienna (AT), Inserm (FR), University of Freiburg (DE), University of Salzburg (AT), Universität Ulm (DE), Université de Montpellier (FR), University Medical Center Freiburg (DE), German Red Cross (DE), Children's Health Ireland at Crumlin (IE), Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR), Centre Hospitalier Universitaire de Montpellier (FR), Centre de Référence des Maladies Autoinflammatoires et des Amyloses (FR), CeGaT (Germany) (DE), University Children's Hospital Zurich (CH), Bernstein Center for Computational Neuroscience Tübingen (DE), Max Planck Institute of Immunobiology and Epigenetics (DE), University of Tübingen (DE)
Openalex Percentile: Top 36%
Immunodeficiency and Autoimmune Disorders
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