Alterations in Monoamine Metabolites in Alzheimer's Disease: A Comprehensive Meta‐Analysis of Cerebrospinal Fluid Levels
5-HIAA and HVA concentrations were significantly lower in AD patients compared to healthy controls, suggesting dysfunction in the serotonergic and dopaminergic systems. Conversely, MHPG levels were elevated, pointing to potential increased norepinephrine breakdown. DOPAC levels did not show a significant difference. These results underscore the dysregulation of monoaminergic neurotransmission in AD, with the need for further studies to validate and utilize these findings for potential therapeutic target identification.
Authors
- Mainak Bardhan (ORCID: https://orcid.org/0000-0002-4106-409X)
- Victor Ghosh (ORCID: https://orcid.org/0000-0003-0914-1056)
- Anmol Kaur
- Poorvikha Gowda
- Vinay Suresh (ORCID: https://orcid.org/0000-0002-1401-9154)
- P.N. Yadav
- Mohammad Orooj Azmi
- Harshita Agarwa
- Ahmed Y. Azzam
- Alzheimer's Interest and Analytics Group ‐ NeuroStats Network
- Mohammad Hassan
- Muneeb Ahmad Muneer
Institutions
- Andhra University (IN)
- Lady Hardinge Medical College (IN)
- Baptist Hospital of Miami (US)
- Albert Einstein College of Medicine (US)
- Allama Iqbal Medical College (PK)
- King George's Medical University (IN)
- Maulana Azad Medical College (IN)
- Baptist Health South Florida (US)
- Institute of Post Graduate Medical Education and Research (IN)
- Jawaharlal Nehru Medical College (IN)
- St.John's Medical College Hospital (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100217
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00