Cross‐Sectional and Longitudinal Associations of the Pupillary Light Response with Mild Cognitive Impairment
These results demonstrate that aspects of the pupillary light response are significantly associated with MCI at late midlife and predictive of conversion to amnestic MCI over a 6-year follow-up, suggesting its utility as an easily acquired, non-invasive biomarker for risk of cognitive decline and ADRD prior to overt impairment. The observed associations are consistent with either hypoactivity in parasympathetic anticholinergic systems and/or hyperactivity in locus coeruleus-norepinephrine systems in preclinical AD, and possibly dysfunction in photosensitive melanopsin expressing retinal ganglion cells in preclinical AD.
Authors
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- Kristine C. Dell (ORCID: https://orcid.org/0000-0001-8973-4980)
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- Francesca V. Lopez (ORCID: https://orcid.org/0000-0003-0875-7326)
- Eric Granholm (ORCID: https://orcid.org/0000-0003-2040-7951)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Chandra A Reynolds
- the Vietnam Era Twin Study of Aging (VETSA)
- Matthew S. Panizzon
Institutions
- University of Colorado Boulder (US)
- University of California San Diego (US)
- Joint Center for Structural Genomics (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103754
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00