Affective Fluctuations in Depressive and Anxiety Symptomatology Predict Cognitive Performance Decline in Older Adults
In cognitively unimpaired older adults within-subject affective variability is associated with linear decline on cognitive performance over several years. Understanding and accounting for the potential impact of affective fluctuations on cognitive performance may improve trajectory and power estimates in observational and interventional studies, and suggest strategies to mitigate components of cognitive decline.
Authors
- Angela Kuramoto
- David W. Coon (ORCID: https://orcid.org/0000-0002-5224-3886)
- A. Atri
- Carla Jooste
- Farah Shaikh
- Michael H. Malek‐Ahmadi
- Hamzah Al‐Jubouriy
- Kathy O'Connor
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Phoenix (US)
- Banner Sun Health Research Institute (US)
- Banner Alzheimer’s Institute
- Phoenix College (US)
- Arizona State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_101303
- Primary Topic
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00