Lecanemab Subcutaneous Formulation for Maintenance Dosing in Early Alzheimer’s Disease (AD)

Maintenance subcutaneous lecanemab dosing will reduce the burden for subjects and their caregivers associated with lecanemab administration while still maintaining the efficacy observed with lecanemab biweekly treatment. Modeling indicates that maintenance therapy with subcutaneous lecanemab prevents biomarker re-accumulation and has no significant meaningful impact on amyloid or meaningful impact on disease progression compared to the intravenous regimen. A subcutaneous formulation has the potential to improve the lecanemab safety profile with a more patient friendly and convenient route of administration.