Structural Variants Associated with Sporadic Alzheimer's Disease Pathologies and Segregates in Caribbean Hispanics and Non‐Hispanic White Families
Our findings reveal numerous SVs segregating in familial AD across both CH and NHW families, as well as additional SVs linked to sporadic AD. Prioritizing these SVs based on their potential effects on gene function and expression will provide deeper insight into their contributions to both familial and sporadic AD.
Authors
- Martin Medrano (ORCID: https://orcid.org/0000-0003-3673-9088)
- Alexi Runnels (ORCID: https://orcid.org/0000-0002-8592-1444)
- Anna O. Basile (ORCID: https://orcid.org/0000-0001-5112-5880)
- Diones Rivera Mejía (ORCID: https://orcid.org/0000-0001-5935-8005)
- Tamil Iniyan Gunasekaran (ORCID: https://orcid.org/0000-0002-8639-5060)
- Michael C. Zody (ORCID: https://orcid.org/0000-0001-6594-7199)
- Debby W. Tsuang (ORCID: https://orcid.org/0000-0002-4716-1894)
- André Corvelo (ORCID: https://orcid.org/0000-0003-0989-7806)
- H. Wang (ORCID: https://orcid.org/0000-0001-8299-1247)
- Roger N. Rosenberg
- Uday S. Evani (ORCID: https://orcid.org/0009-0002-2057-4514)
- Wayne E. Clarke (ORCID: https://orcid.org/0000-0003-2471-0712)
- Giuseppe Narzisi (ORCID: https://orcid.org/0000-0003-1118-8849)
- Robert A. Sweet (ORCID: https://orcid.org/0000-0001-9154-9709)
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Rafael Lantigua (ORCID: https://orcid.org/0000-0003-4854-7331)
- Gerald D. Schellenberg
- Brad F Boeve
- Wan‐Ping Lee
- Robert S. Wilson
- Badri N. Vardarajan
- Carlos Cruchaga
- Jonathan L Haines
- Alison M. Goate
- Marta S. Byrska‐Bishop
- Tatiana M. Foroud
- Margaret Pericak‐Vance
- David A. A. Bennett
- Richard Mayeux
- Clifton L. Dalgard
- Kelley M. Faber
- Rajeeva O. Musunuri
Institutions
- Rush University Medical Center (US)
- NewYork–Presbyterian Hospital (US)
- University of Miami (US)
- Uniformed Services University of the Health Sciences (US)
- Pontificia Universidad Católica Madre y Maestra (DO)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- New York Hospital Queens (US)
- Instituto Tecnológico de Santo Domingo (DO)
- VA Puget Sound Health Care System (US)
- Southwestern Medical Center (US)
- Geriatric Research Education and Clinical Center (US)
- Universidad Nacional Pedro Henríquez Ureña (DO)
- Mayo Clinic in Arizona (US)
- Pediatrics and Genetics (US)
- New York Genome Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107342
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00