Serum placental growth factor as a biomarker of cerebrovascular changes in Alzheimer's disease
Serum PlGF is a promising biomarker of CVD, especially cerebral microbleeds, in AD. Our results suggest that its role may specifically apply to certain subpopulations such as APOE4 carriers. In the era of anti-amyloid therapies, understanding mechanisms linking PlGF to CVD is of utmost importance to evaluate its potential for safety and monitoring purposes.
Authors
- Caroline Dallaire‐Théroux (ORCID: https://orcid.org/0000-0003-1729-2209)
- Vincent Émond (ORCID: https://orcid.org/0009-0004-8931-5785)
- Olivier Potvin (ORCID: https://orcid.org/0000-0001-9487-1920)
- Rosalie Juliette Cottez (ORCID: https://orcid.org/0009-0004-6233-9074)
- Frederic Calon
- Mahsa Dadar
- Cyntia Tremblay
Institutions
- Douglas Mental Health University Institute (CA)
- Montreal Heart Institute (CA)
- Centre hospitalier universitaire de Québec (CA)
- Université Laval (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100391
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00