Baseline geriatric 8 (G8) screening tool predicts overall survival in metastatic urothelial carcinoma treated with immune checkpoint inhibitors
The G8 screening tool effectively predicts OS in older mUC patients treated with ICIs, highlighting its potential utility in clinical decision-making. Frail patients, as identified by the G8, had significantly worse survival outcomes, underscoring the need for tailored therapeutic approaches in this vulnerable population. Further studies are warranted to validate these findings and explore interventions that may improve outcomes for frail, older patients with mUC.
Authors
- Julie M. Shabto (ORCID: https://orcid.org/0000-0003-0991-9294)
- Bradley Curtis Carthon
- Dylan J. Martini (ORCID: https://orcid.org/0000-0002-0843-1222)
- Christopher H. Rhee (ORCID: https://orcid.org/0000-0001-9692-0714)
- Y. Liu
- Subir Goyal (ORCID: https://orcid.org/0000-0003-1737-7771)
- Jacqueline T. Brown (ORCID: https://orcid.org/0000-0002-1885-0906)
- Bassel Nazha (ORCID: https://orcid.org/0000-0001-6385-1329)
- Mehmet Asim Bilen
- Omer Kucuk
Institutions
- Emory University (US)
- University of Georgia (US)
- Augusta University (US)
- Augusta University Health (US)
- Massachusetts General Hospital (US)
- Piedmont Cancer Institute (US)
- Columbia University (US)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1093/oncolo/oyaf361
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00