Quantification of EphA4 Turnover Rate and Subsequent Validation of Target Engagement for E2025, a Novel Anti‐EphA4 Antibody, in Human Neural Cells
SILK technology demonstrated that E2025 increased the turnover rate of EphA4 in a concentration-dependent manner. Therefore, this method may be applicable for assessing the pharmacodynamic effects of E2025. References [1] Verma, M., Chopra, M. & Kumar, H. Cell Mol Neurobiol 43, 3375-3391, (2023). [2] Vargas, L. M., Cerpa, W., Munoz, F. J., Zanlungo, S. & Alvarez, A. R. Biochim Biophys Acta Mol Basis Dis 1864, 1148-1159, (2018).
Authors
- Kazuto Yamazaki (ORCID: https://orcid.org/0000-0002-4130-3740)
- Takeo Kamakura
- Kazuhiro Tahara (ORCID: https://orcid.org/0009-0000-4899-9990)
- Akio Yamada (ORCID: https://orcid.org/0000-0001-7260-4565)
- Kanta Horie (ORCID: https://orcid.org/0000-0001-7736-2614)
- Eiji Inoue (ORCID: https://orcid.org/0000-0003-2143-0491)
Institutions
- Eisai (United States) (US)
- Eisai (Japan) (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_096834
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00