Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

In genetic FTD, females show cognitive resilience in early disease stages followed by steeper clinical declines later in disease. Baseline NfL may be a less sensitive prognostic tool for clinical progression in females with FTD-causing mutations, especially early in disease.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_100820
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

Kaitlin B Casaletto
Alzheimer s & Dementia
Amyotrophic Lateral Sclerosis Research
article

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

Kaitlin B Casaletto
article en

Abstract

In genetic FTD, females show cognitive resilience in early disease stages followed by steeper clinical declines later in disease. Baseline NfL may be a less sensitive prognostic tool for clinical progression in females with FTD-causing mutations, especially early in disease.

Alzheimer s & DementiaVol. 21(S3)
University of California, San Francisco (US), University Memory and Aging Center (US)
Openalex Percentile: Top 31%
Amyotrophic Lateral Sclerosis Research
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Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia — Kaitlin B Casaletto · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS