Cerebral focal WMH co‐locate with transcerebral intramedullary vessels and can vary over time
Most fWMH were distributed along DMVs, particularly. Their dynamic progression was compatible with being fluid in nature and not necessarily indicative of ischemiaas previously thought. fWMH could relate to multiple underlying pathologies, but venous insufficiency of deep intramedullary venules may be an important substrate of fWMH in AD and aging.
Authors
- Melissa F. Holmes
- Julia Keith (ORCID: https://orcid.org/0000-0003-1519-6731)
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- Mario Masellis
- Fuqiang Gao
- Sandra E. Black
- Richard H. Swartz
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Scarborough Health Network (CA)
- Health Sciences Centre (CA)
- Ontario Brain Institute (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099743
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00