A rare variant polygenic risk score for Late‐Onset Alzheimer's Disease demonstrates trans‐ethnic predictive power
rvPRS-AD is the first genetic instrument that leverages rare variants in a polygenic framework to predict LOAD risk across ancestrally diverse populations in a manner that is independent of common variant predictors.
Authors
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Shihong Mao (ORCID: https://orcid.org/0000-0002-0881-2412)
- Basilio Cieza
- Guillaume Paré (ORCID: https://orcid.org/0000-0002-6795-4760)
- Ricky Lali (ORCID: https://orcid.org/0000-0002-9689-9414)
Institutions
- NewYork–Presbyterian Hospital (US)
- Hamilton Regional Laboratory Medicine Program (CA)
- Presbyterian Hospital (US)
- Hamilton Health Sciences (CA)
- Columbia University (US)
- McMaster University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106838
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00