Chemotherapy‐Associated Brain Morphological Alterations in Breast Cancer: Implications for Cognitive Decline and Neurodegenerative Risks

The deep brain regions showing significant differences between the two groups may align with those affected in other conditions, such as Small Vessels Disease and Vascular Dementia, with some belonging to the Default Mode Network, which is also compromised in AD. Chemotherapy-induced neuroinflammation could potentially disrupt the neurovascular unit, induce vascular toxicity, and lead to brain morphological changes contributing to the cognitive impairment underlying the Chemobrain phenotype. Reference 1. Fleming et al. "Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management" BMJ.2023Mar15;380:e071726.