Associations Between APOE Genotypes and Vascular Pathology Lesions in Alzheimer's Disease: Insights from the NACC Dataset
Our findings suggest that carrying at least one APOE ɛ4 allele increases the risk of arteriolosclerosis and hippocampal sclerosis, while the presence of at least one APOE ɛ2 increased the risk of large arterial infarcts. TDP-43 proteinopathy modifies these effects, with APOE ε4 showing stronger vascular and neurodegenerative associations in those with absent TDP-43 proteinopathy but not in those with TDP-43 proteinopathy.
Authors
- Alfred K. Njamnshi (ORCID: https://orcid.org/0000-0003-0052-1511)
- Yannick N. Wadop (ORCID: https://orcid.org/0000-0002-8955-1874)
- Xueqiu Jian (ORCID: https://orcid.org/0000-0002-0313-6494)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- José E Cavazos (ORCID: https://orcid.org/0000-0001-5777-2608)
- Habil Zare (ORCID: https://orcid.org/0000-0001-5902-6238)
- Apochi Obed Okwoli (ORCID: https://orcid.org/0000-0002-4144-3137)
- Biniyam Ayele
- Rebecca Bernal
- Jayandra J. Himali
- Alice Nono Djotsa
- Alfred N. Fonteh
- the STAC ‐ African Initiative on Bioinformatics Online Training in Neurodegenerative Diseases (AI‐BOND)
- Sudha Seshadri
- Margaret E Flanagan
- Crystal Wiedner
- Agustin Ruiz
- Nkouonlack Cyrille
- Muralidharan Sargurupremraj
Institutions
- Boston University (US)
- Huntington Medical Research Institutes (US)
- Michael E. DeBakey VA Medical Center (US)
- Université de Yaoundé I (CM)
- National Forensic Sciences University (IN)
- Texas A&M University – San Antonio (US)
- University of Miami (US)
- The University of Texas at San Antonio Health Science Center (US)
- Baylor College of Medicine (US)
- Universitat Internacional de Catalunya (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Urology San Antonio (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- Dr. John T. Macdonald Foundation (US)
- Catholic University of Central Africa (CM)
- Global Brain Health Institute (US)
- Addis Ababa University (ET)
- The University of Texas at San Antonio (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107130
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00