Risk factors and clinical relevance of MRI vascular markers in the U.S. POINTER study: a cross‐cohort comparison with the Framingham Heart Study

Our study explores four imaging markers representing diverse mechanisms by which CVD could impact brain structure and function in the POINTER and FHS studies. Despite differences in cohort characteristics, we found mostly consistent CVD relationships with demographic, VRF, and cognitive measures between cohorts which supports the generalizability of the relation of these markers with VRF and cognition identified in the POINTER cohort.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_100134
Primary Topic
Cerebrospinal fluid and hydrocephalus
Type
article
Field-Weighted Citation Impact
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article

Risk factors and clinical relevance of MRI vascular markers in the U.S. POINTER study: a cross‐cohort comparison with the Framingham Heart Study

Heather M. Snyder, Sudha S. Seshadri, Jose Rafael Romero, Laura D. Baker et al.
Alzheimer s & Dementia
Cerebrospinal fluid and hydrocephalus
article

Risk factors and clinical relevance of MRI vascular markers in the U.S. POINTER study: a cross‐cohort comparison with the Framingham Heart Study

Heather M. Snyder, Sudha S. Seshadri, Jose Rafael Romero, Laura D. Baker, Pauline Maillard, Alexa S Beiser, Susan M. Landau, the US POINTER Study Group, Claudia L Satizabal, Charles S. DeCarli, Prashanthi Vemuri
article en

Abstract

Our study explores four imaging markers representing diverse mechanisms by which CVD could impact brain structure and function in the POINTER and FHS studies. Despite differences in cohort characteristics, we found mostly consistent CVD relationships with demographic, VRF, and cognitive measures between cohorts which supports the generalizability of the relation of these markers with VRF and cognition identified in the POINTER cohort.

Alzheimer s & DementiaVol. 21(S2)
Boston University (US), Alzheimer's Association (US), The University of Texas at San Antonio Health Science Center (US), Institute for Neurodegenerative Disorders (US), Mayo Clinic in Arizona (US), The University of Texas at San Antonio (US), Wake Forest University (US), University of California, Davis (US), University of California, Berkeley (US)
Good health and well-being
Openalex Percentile: Top 37%
Cerebrospinal fluid and hydrocephalus
DOIOpen Access PDFOpenAlex
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Risk factors and clinical relevance of MRI vascular markers in the U.S. POINTER study: a cross‐cohort comparison with the Framingham Heart Study — Heather M. Snyder, Sudha S. Seshadri, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS