Genome‐Wide by Environment Interaction Studies of PM <sub>2.5</sub> and Alzheheimer's Genetic Risk Across Brain Imaging Phenotypes in UK Biobank
This study delves into the gene-environment effect of PM<sub>2.5</sub> in genetic architecture of Alzheimer's disease, identifying novel risk loci associated with GxE effects. Our findings illustrate a big picture of genetic architecture of different brain structures and functions interacting with common air pollutants like PM<sub>2.5</sub>.
Authors
- Samir N. P. Kelada (ORCID: https://orcid.org/0000-0003-2676-9232)
- Zehui Sun
- Tengfei Li
- Jason L Stein
- Hongtu Zhu
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_097952
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00