Blood‐based transcriptional risk score for Parkinson's disease is associated with cognitive decline in Alzheimer's disease
Our findings suggest that blood-based PD-TRS may reflect the CSF alpha-synuclein SAA positivity and longitudinal cognitive decline in comorbid alpha-synucleinopathy in AD, advancing the identification of a blood-based biomarker to assess mixed pathology in AD.
Authors
- S Kim
- Paula J. Bice (ORCID: https://orcid.org/0000-0001-5357-9966)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Andrew Joel Saykin
- Kwangsik Nho
- Young Ho Park
- Michael S. W. Weiner
- Jung‐Min Pyun
Institutions
- University of California, San Francisco (US)
- Soonchunhyang University Hospital Seoul (KR)
- Seoul National University Bundang Hospital (KR)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Northern California Institute for Research and Education (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099214
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00