Heterogeneity in the Genetic Architecture of Alzheimer disease (AD) across Ancestry Groups
While AD pathobiology is consistent across affected individuals, the effects of genetic variation may differ greatly across ancestry groups. Our estimates show a low to modest shared genetic component of AD risk across ancestry groups, however these are likely underestimates of real effects. These findings highlight that ancestry-specific genetic contributors for AD remain to be identified.
Authors
- Penelope Benchek (ORCID: https://orcid.org/0000-0002-7385-087X)
- Nicholas R. Ray
- R. Mayeux
- Jiji T. Kurup (ORCID: https://orcid.org/0000-0001-6291-3911)
- G W Beecham
- Sven‐Thorsten Dietrich
- Sterling C. Johnson
- Bush Wh
- Adam C Naj
- Li‐San Wang
- Giuseppe Tosto
- Margaret Pericak‐Vance
- Rufus O. Akinyemi
- Lindsay A. Farrer
- Christiane Reitz
- Kara L Hamilton‐Nelson
- Jonathan L Haines
- Goldie S Byrd
- Jeffery M Vance
Institutions
- Boston University (US)
- University of Miami (US)
- University of Ibadan (NG)
- Columbia University Irving Medical Center (US)
- Dr. John T. Macdonald Foundation (US)
- Wake Forest University (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107285
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00