Cholinergic Dysregulation in Alzheimer's Disease: A Meta‐Analysis of Enzymatic Activity and Regional Alterations in Brain and Cerebrospinal Fluid
AChE showed significantly reduced activity in CSF and particularly in the temporal, frontal, hippocampal, and parietal brain regions. BChE exhibited significant reduction in CSF activity, and choline levels were significantly decreased in brain regions. ChAT showed significant reduction in the frontal, temporal, hippocampal, and occipital brain regions. Further research is required to validate these findings.
Authors
- Mainak Bardhan (ORCID: https://orcid.org/0000-0002-4106-409X)
- Harshita Agarwal
- Victor Ghosh (ORCID: https://orcid.org/0000-0003-0914-1056)
- Anmol Kaur
- Poorvikha Gowda
- Vinay Suresh (ORCID: https://orcid.org/0000-0002-1401-9154)
- P.N. Yadav
- Mohammad Orooj Azmi
- Ahmed Y. Azzam
- Alzheimer's Interest and Analytics Group ‐ NeuroStats Network
- Mohammad Hassan
- Muneeb Ahmad Muneer
Institutions
- Andhra University (IN)
- Lady Hardinge Medical College (IN)
- Baptist Hospital of Miami (US)
- Albert Einstein College of Medicine (US)
- Allama Iqbal Medical College (PK)
- King George's Medical University (IN)
- Maulana Azad Medical College (IN)
- Baptist Health South Florida (US)
- Institute of Post Graduate Medical Education and Research (IN)
- Jawaharlal Nehru Medical College (IN)
- St.John's Medical College Hospital (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100992
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00