CTHRC1/TGF-β/Smad axis serves as therapeutic targets in inhibiting oral squamous cell carcinoma by mediating ferroptosis
Our findings indicate that knockdown of CTHRC1 stimulates ferroptosis in OSCC through inhibiting TGF-β/Smad pathway, which provides important experimental data and theoretical basis for the management, diagnosis, and treatment of OSCC.
Authors
- Guixian Mu
- Linli Xie
- Yongchun Chang
- Yiming Jiao
- Shihao Huang
- Yu Feng
Institutions
- Weifang Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Dongguan People’s Hospital (CN)
- Jinan Stomatological Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1007/s12672-025-04354-6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00