Optical Coherent Tomography as a Potential Biomarker for Logopenic Variant Primary Progressive Aphasia: A Cross‐Sectional Prospective Study

Our findings suggest decreased RNFL thickness and reduced FAZ circularity in lvPPA. Decreased RNFL thickness reflects neuronal degeneration and its underlying mechanisms include retinal amyloid accumulation or retrograde degeneration. This suggests that amyloid-induced brain atrophy leads to a lack of trophic factors, resulting in thinning of the RNFL while reduced FAZ circularity could signal early vascular alterations induced by amyloid. Altogether, these findings suggest that OCT and OCT-A could serve as valuable biomarkers for lvPPA, thus enhancing early diagnosis.