4R Tau Drives Endolysosomal Dysfunction in VCP‐Related Frontotemporal Dementia

Our findings demonstrate that 4R tau dysregulation contributes to neurodegeneration by disrupting endolysosomal and autophagic function in FTD. Targeting tau isoform balance may offer a promising therapeutic approach for VCP-related FTD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105883
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

4R Tau Drives Endolysosomal Dysfunction in VCP‐Related Frontotemporal Dementia

Christy Hung
Alzheimer s & Dementia
Amyotrophic Lateral Sclerosis Research
article

4R Tau Drives Endolysosomal Dysfunction in VCP‐Related Frontotemporal Dementia

Christy Hung
article en

Abstract

Our findings demonstrate that 4R tau dysregulation contributes to neurodegeneration by disrupting endolysosomal and autophagic function in FTD. Targeting tau isoform balance may offer a promising therapeutic approach for VCP-related FTD.

Alzheimer s & DementiaVol. 21(S1)
City University of Hong Kong (HK)
Openalex Percentile: Top 31%
Amyotrophic Lateral Sclerosis Research
DOIOpen Access PDFOpenAlex
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4R Tau Drives Endolysosomal Dysfunction in VCP‐Related Frontotemporal Dementia — Christy Hung · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS