Cognitive Performance and Biomarker Profiles in Puipui Malu Manatu ( <i>Preserving Memory</i> ) ‐ a Population‐Based Prevalence Study ADRD in American Samoa

The prevalence of cognitive impairment in American Samoa is 31%. Most cases of cognitive impairment appear not to be related to AD pathology and ApoE ε4 does not appear to be a risk factor. Our study findings suggest that (a) exploration of non-AD biomarkers is needed, (b) cultural tailoring and re-examination of inter-individual normative values for cognitive tests are important, and (c) intra-individual change as measured by the CDR may be a more valid method of dementia detection.