Plasma Phosphorylated Tau 217 predicts cognitive and functional deterioration across clinical stages of Alzheimer's disease
Plasma p-tau217, measured using a commercially available immunoassay, was associated with cognitive and functional decline in AD. These findings highlight the potential of plasma p-tau217 for use in routine clinical practice to monitor and prognosticate AD progression.
Authors
- Sara Rubio‐Guerra (ORCID: https://orcid.org/0000-0001-7652-8029)
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Sílvia Valldeneu (ORCID: https://orcid.org/0000-0003-3497-886X)
- Lucía Maure‐Blesa
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Burak Arslan (ORCID: https://orcid.org/0000-0001-7229-3226)
- Ignacio Illán‐Gala (ORCID: https://orcid.org/0000-0002-5418-2052)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- Laia Montoliu‐Gaya (ORCID: https://orcid.org/0000-0001-7684-6318)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- Mireia Espallargues Carreras
- Nuole Zhu (ORCID: https://orcid.org/0000-0002-0015-9455)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Kaj Blennow
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Judit Selma‐González (ORCID: https://orcid.org/0009-0006-1021-4653)
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Esther Álvarez‐Sánchez
- Jesus Garcia Castro
- Daniel Alcolea
- Alberto Lleó
- Oriol Lorente
- Miguel A Santos‐Santos
- Isabel Sala
- Elena Vera
- Henrik Zetterberg
- Nicholas J. Ashton
- Oriol Dols‐Icardo
- Lídia Vaqué‐Alcázar
- María Belén Sánchez‐Saudinós
- Íñigo Rodríguez‐Baz
Institutions
- Universitat Autònoma de Barcelona (ES)
- University of Arizona (US)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100198
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00