Plasma Phosphorylated Tau 217 predicts cognitive and functional deterioration across clinical stages of Alzheimer's disease

Plasma p-tau217, measured using a commercially available immunoassay, was associated with cognitive and functional decline in AD. These findings highlight the potential of plasma p-tau217 for use in routine clinical practice to monitor and prognosticate AD progression.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_100198
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Plasma Phosphorylated Tau 217 predicts cognitive and functional deterioration across clinical stages of Alzheimer's disease

Sara Rubio‐Guerra, Olivia Belbin, Sílvia Valldeneu, Lucía Maure‐Blesa et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
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Plasma Phosphorylated Tau 217 predicts cognitive and functional deterioration across clinical stages of Alzheimer's disease

Sara Rubio‐Guerra, Olivia Belbin, Sílvia Valldeneu, Lucía Maure‐Blesa, Laura Videla, Burak Arslan, Ignacio Illán‐Gala, Isabel Barroeta, Laia Montoliu‐Gaya, María Carmona‐Iragui, Mireia Espallargues Carreras, Nuole Zhu, José Enrique Arriola‐Infante, Kaj Blennow, Alexandre Bejanin, Judit Selma‐González, Javier Arranz, Juan M. Fortea, Esther Álvarez‐Sánchez, Jesus Garcia Castro, Daniel Alcolea, Alberto Lleó, Oriol Lorente, Miguel A Santos‐Santos, Isabel Sala, Elena Vera, Henrik Zetterberg, Nicholas J. Ashton, Oriol Dols‐Icardo, Lídia Vaqué‐Alcázar, María Belén Sánchez‐Saudinós, Íñigo Rodríguez‐Baz
article en

Abstract

Plasma p-tau217, measured using a commercially available immunoassay, was associated with cognitive and functional decline in AD. These findings highlight the potential of plasma p-tau217 for use in routine clinical practice to monitor and prognosticate AD progression.

Alzheimer s & DementiaVol. 21(S2)
Universitat Autònoma de Barcelona (ES), University of Arizona (US), Instituto de Salud Carlos III (ES), Hospital de Sant Pau (ES), Biomedical Research Networking Center on Neurodegenerative Diseases (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), University of Gothenburg (SE)
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
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