Neuropsychiatric symptoms across levels of cognition in Alzheimer's disease in Down Syndrome and late‐life sporadic Alzheimer's disease

Our findings suggest similar relationships between cognitive status and NPS severity across syndromes, suggesting that the shared amyloid pathology may be contributing across the two groups. These results also highlight the importance of NPS in early diagnosis, treatment, and caregiving. Further research is needed to validate and expand upon these findings.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_101619
Primary Topic
Down syndrome and intellectual disability research
Type
article
Field-Weighted Citation Impact
0.00
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article

Neuropsychiatric symptoms across levels of cognition in Alzheimer's disease in Down Syndrome and late‐life sporadic Alzheimer's disease

Christy Hom, David L. Sultzer, Daniel L. Gillen, Ira T. Lott et al.
Alzheimer s & Dementia
Down syndrome and intellectual disability research
article

Neuropsychiatric symptoms across levels of cognition in Alzheimer's disease in Down Syndrome and late‐life sporadic Alzheimer's disease

Christy Hom, David L. Sultzer, Daniel L. Gillen, Ira T. Lott, C. Enjey Lin, Christina M. Magana‐Ramirez, Lidio Jaimes, Srisai Saavarni Chilukuri, Noah McMahon, Ryan Kuhlman, Tiffany M Hu, Elizabeth Head
article en

Abstract

Our findings suggest similar relationships between cognitive status and NPS severity across syndromes, suggesting that the shared amyloid pathology may be contributing across the two groups. These results also highlight the importance of NPS in early diagnosis, treatment, and caregiving. Further research is needed to validate and expand upon these findings.

Alzheimer s & DementiaVol. 21(S3)
University of California, Riverside (US), Alzheimer's Association (US), University of Georgia (US), University of Washington (US), University of California, Irvine (US), University of Florida (US), University of California San Diego (US), UC Irvine Health (US)
Openalex Percentile: Top 27%
Down syndrome and intellectual disability research
DOIOpen Access PDFOpenAlex
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Neuropsychiatric symptoms across levels of cognition in Alzheimer's disease in Down Syndrome and late‐life sporadic Alzheimer's disease — Christy Hom, David L. Sultzer, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS