Cerebrospinal fluid proteome associations with neuropsychiatric symptoms in Alzheimer's disease
Using untargeted CSF proteomics, we identified different protein profiles related to overall NPS severity and presence of individual symptoms. First results suggest distinct pathological mechanisms involved in NPS, which may represent specific intervention targets.
Authors
- Julius Popp (ORCID: https://orcid.org/0000-0002-0068-0312)
- Miriam Rabl (ORCID: https://orcid.org/0000-0002-3189-6554)
- Pyry Helkkula (ORCID: https://orcid.org/0000-0001-5094-3208)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Pieter Jelle Visser
- Willem Lucas Hartog
- Wiesje M. van der Flier
- Betty M. Tijms
- Charlotte E. Teunissen
Institutions
- Karolinska Institutet (SE)
- Maastricht University (NL)
- University Hospital of Zurich (CH)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Lausanne (CH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103643
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00