Delayed niacin skin flush response and cognitive impairment in Late‐Life Depression
LLD with CI exhibited a delayed NSFR. Delayed NSFR proved effective in distinguishing cognitive impairment in LLD, suggesting that NSFR could serve as a potential biomarker for LLD with CI. Furthermore, in patients with LLD, a delayed NSFR at baseline predicts poorer cognitive outcomes. These insights open new avenues for research into the mechanisms underlying CI in LLD and offer fresh perspectives on potential therapeutic targets.
Authors
- Yijia Chen (ORCID: https://orcid.org/0000-0002-9295-5028)
- Qi Qiu (ORCID: https://orcid.org/0000-0001-7756-7134)
- Yang Yang (ORCID: https://orcid.org/0000-0001-5720-773X)
- Dandan Wang (ORCID: https://orcid.org/0000-0002-5626-8968)
- You Wu (ORCID: https://orcid.org/0000-0001-6592-777X)
- Qianqian Guo
- Chunlin Wan
- Xia Li
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Mental Health Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_097465
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00