Sporadic mixed primary progressive aphasia with semantic / non‐fluent variant phenotypes and GRN mutation: a case report

The mixed PPA-GRN can show multiple levels of language impairment simultaneously altered, such as grammatical, verbal fluency, and semantic, affecting different language pathways, as in this case. The high prevalence of patients with PPA without a family history of FTLD indicates that genetic studies should not be limited to familial cases. Also, GRN mutations are usually present on atypical/mixed PPA phenotypes, suggesting that GRN should be considered primarily in patients with this clinical pattern.