Investigating the Effects of Frontotemporal Dementia‐Linked Genetic Mutations on Inequity Aversion Prior to Clinical Onset

This study found no significant differences in inequity aversion between mutation carriers and non-carriers before the onset of FTD symptoms. These findings suggest that behavioral markers of cognitive changes in FTD may emerge only within a narrow temporal window before disease onset, presenting challenges for early detection in asymptomatic individuals. Future studies should explore complementary approaches to identify prodromal biomarkers of FTD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_102530
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
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article

Investigating the Effects of Frontotemporal Dementia‐Linked Genetic Mutations on Inequity Aversion Prior to Clinical Onset

Chenyu Wang
Alzheimer s & Dementia
Amyotrophic Lateral Sclerosis Research
article

Investigating the Effects of Frontotemporal Dementia‐Linked Genetic Mutations on Inequity Aversion Prior to Clinical Onset

Chenyu Wang
article en

Abstract

This study found no significant differences in inequity aversion between mutation carriers and non-carriers before the onset of FTD symptoms. These findings suggest that behavioral markers of cognitive changes in FTD may emerge only within a narrow temporal window before disease onset, presenting challenges for early detection in asymptomatic individuals. Future studies should explore complementary approaches to identify prodromal biomarkers of FTD.

Alzheimer s & DementiaVol. 21(S3)
University of California, San Francisco (US), University of California San Francisco Medical Center (US)
Openalex Percentile: Top 31%
Amyotrophic Lateral Sclerosis Research
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